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Assessment and medication application The analgesia test was performed on the mice receiving morphine prior to the tested agents (i), and on the mice receiving no morphine prior to tested agents (ii), using the hot plate (Ugo Basille, Italy)

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First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization

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The clinical sites, sample sources (CENTER TBI [31, 41] and the CanTBI bank [30]), severity of TBI, health status of controls, time points and methods for characterizing lipid metabolism varied between trials and contributed to the observed differences